English

=Laboratory of Nutrition Chemistry, Osaka Prefecture University=

 

Staffs

Professor
Ryoichi Yamaji, Ph.D.

yamaji#biochem.osakafu-u.ac.jp

 

Lecturer
Naoki Harada, Ph.D.

harada#biochem.osakafu-u.ac.jp

 

Please change# to @, when you send an e-mail.

 

Publications

 

2016
1. Castration influences intestinal microflora and induces abdominal obesity in high-fat diet-fed mice.
Harada N, Hanaoka R, Horiuchi H, Kitakaze T, Mitani T, Inui H, and Yamaji R.
[Sci. Rep., 6, 23001, 2016]

2. pVHL-mediated degradation of HIF-2α regulates estrogen receptor α expression in normoxic breast cancer cells.
Higashimura Y, Kitakaze T, Harada N, Inui H, Nakano Y, and Yamaji R.
[FEBS Lett., 590, 2690-2699, 2016]

3. The collagen derived dipeptide hydroxyprolyl-glycine promotes C2C12 myoblast differentiation and myotube hypertrophy.
Kitakaze T, Sakamoto T, Kitano T, Inoue N, Sugiura F, Harada N, and Yamaji R.
[Biochem. Biophys. Res. Commun., 473, 1292-1297, 2016]

4. Mogrol derived from Siraitia grosvenorii mogrosides suppresses 3T3-L1 adipocyte differentiation by reducing cAMP-response element-binding protein phosphorylation and increasing AMP-activated protein kinase phosphorylation.
Harada N, Ishihara M, Horiuchi H, Ito Y, Tabata H, Suzuki YA, Nakano Y, Yamaji R, and Inui H.
[PLoS One, 11, e0162252, 2016]

5. Hypogonadism alters cecal and fecal microbiota in male mice.
Harada N, Hanaoka R, Hanada K, Izawa T, Inui H, and Yamaji R.
[Gut Microbes, 7, 533-539, 2016]

 

2015
1. Autophagic degradation of the androgen receptor mediated by increased phosphorylation of p62 suppresses apoptosis in hypoxia.
Mitani T, Minami M, Harada N, Ashida H, and Yamaji R.
[Cell. Signal., 27, 1994-2001, 2015]

2. Androgen receptor silences thioredoxin-interacting protein and competitively inhibits glucocorticoid receptor-mediated apoptosis in pancreatic β-cells.
Harada N, Katsuki T, Takahashi Y, Masuda T, Yoshinaga M, Adachi T, Izawa T, Kuwamura M, Nakano Y, Yamaji R, and Inui H.
[J. Cell. Biochem., 116, 998-1006, 2015]

3. Female-specific regulation of skeletal muscle mass by USP19 in young mice.
Ogawa M, Kitakaze T, Harada N, and Yamaji R.
[J. Endocrinol., 225, 135-145, 2015]

4. β-Carotene increases muscle mass and hypertrophy in the soleus muscle in mice.
Kitakaze T, Harada N, Imagita H, and Yamaji R.
[J. Nutr. Sci. Vitaminol., 61, 481-487, 2015]

5. Protein arginine metyltransferase 10 is required for androgen-dependent proliferation of LNCaP prostate cancer cells.
Harada N, Takagi T, Nakano Y, Yamaji R, and Inui H.
[Biosci. Biotechnol. Biochem., 79, 1430-1437, 2015]

6. Competitive and compensatory effects of androgen signaling and glucocorticoid signaling.
Harada N, Inui H, and Yamaji R.
[Receptors Clin. Investig., 2, e785, 2015]

7. Inhibitory effects of Eucalyptus and Banaba leaf extracts on nonalcoholic steatohepatitis induced by a high-fructose/high-glucose diet in rats.
Takahashi Y, Sugimoto K, Soejima Y, Kumagai A, Koeda T, Shojo A, Nakagawa K, Harada N, Yamaji R, Inui H, Yamanouchi T, and Fukusato T.
[Biomed. Res. Int., 2015, 296207, 2015]

8. Glyceraldehyde-3-phosphate dehydrogenase aggregates accelerate amyloid-β amyloidogenesis in Alzheimer disease.
Itakura M, Nakajima H, Kubo T, Semi Y, Kume S, Higashida S, Kaneshige A, Kuwamura M, Harada N, Azuma YT, Yamaji R, Inui T, and Takeuchi T.
[J. Biol. Chem., 290, 26072-26087, 2015]

9. Construction of sensitive reporter assay yeasts for comprehensive detection of ligand activities of human corticosteroid receptors through inactivation of CWP and PDR genes.
Ito-Harashima S, Shiizaki K, Kawanishi M, Kakiuchi K, Onishi K, Yamaji R, and Yagi T.
[J. Pharmacol. Toxicol. Methods, 74, 41-52, 2015]

 

 

2014
1. Resveratrol reduces the hypoxia-induced resistance to doxorubicin in breast cancer cells.
Mitani T, Ito Y, Harada N, Nakano Y, Inui H, Ashida H, and Yamaji R.
[J. Nutr. Sci. Vitaminol., 60, 122-128, 2014]

2. Resveratrol inhibits hypoxia-inducible factor-1α-mediated androgen receptor signaling and represses tumor progression in castration-resistant prostate cancer.
Mitani T, Harada N, Tanimori S, Nakano Y, Inui H, and Yamaji R.
[J. Nutr. Sci. Vitaminol., 60, 276-282, 2014]

3. S-Equol enantioselectively activates cAMP-protein kinase A signaling and reduces alloxan-induced cell death in INS-1 pancreatic β-cells.
Horiuchi H, Harada N, Adachi T, Nakano Y, Inui H, and Yamaji R.
[J. Nutr. Sci. Vitaminol., 60, 291-296, 2014]

4. Dodecylamine derivative of hydroxocobalamin acts as a potent inhibitor of cobalamin-dependent methionine synthase in mammalian cultured COS-7 cells.
Bito T, Yasui M, Iwaki T, Yabuta Y, Ichiyanagi T, Yamaji R, Nakano Y, Inui H, and Watanabe F.
[Food Nutr. Sci., 5, 1311-1318, 2014]

 

2013
1. The preventive effect of β-carotene on denervation-induced soleus muscle atrophy in mice.
Ogawa M, Kariya Y, Kitakaze T, Yamaji R, Harada N, Sakamoto T, Hosotani K, Nakano Y, and Inui H.
[Br. J. Nutr., 109, 1349-1358, 2013]

2. Identification of carbonyl reductase 1 as a resveratrol-binding protein by affinity chromatography using 4´-amino-3,5-dihydroxy-trans-stilbene.
Ito Y, Mitani T, Harada N, Isayama A, Tanimori S, Takenaka S, Nakano Y, Inui H, and Yamaji R.
[J. Nutr. Sci. Vitaminol., 59, 358-64, 2013]

3. Oligosaccharides from agar inhibit murine intestinal inflammation through the induction of heme oxygenase-1 expression.
Higashimura Y, Naito Y, Takagi T, Mizushima K, Hirai Y, Harusato A, Ohnogi, H, Yamaji R, Inui H, Nakano Y, and Yoshikawa T.
[J. Gastroenterol., 48, 897-909, 2013]

4. Biochemical characterization of a GH53 endo-β-1,4-galactanase and GH35 exo-β-1,4-galactanase from Penicillium chrysogenum.
Sakamoto T, Nishimura Y, Makino Y, Sunagawa Y, and Harada N.
[Appl. Microbiol. Biotechnol., 97, 2895-2906, 2013]

 

2012
1. Coordinated action of hypoxia-inducible factor-1α and β-catenin in androgen receptor signaling.
Mitani T, Harada N, Nakano Y, Inui H, and Yamaji R.
[J. Biol. Chem., 287, 33594-33606, 2012]

2. Androgen deprivation causes truncation of the C-terminal region of androgen receptor in human prostate cancer LNCaP cells.
Harada N, Inoue K, Yamaji R, Nakano Y, and Inui H.
[Cancer Sci., 103, 1022-1027, 2012]

3. Glyceraldehyde-3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability.
Ikeda I, Yamaji R, Irie K, Kioka N, and Murakami A.
[Arch. Biochem. Biophys., 528, 141-147, 2012]

 

2011
1. 17β-Estradiol represses myogenic differentiation by increasing ubiquitin-specific peptidase 19 through estrogen receptor α.
Ogawa M, Yamaji R, Higashimura Y, Harada N, Ashida H, Nakano Y, and Inui H.
[J. Biol. Chem., 286, 41455-41465, 2011]

2. Hypoxia enhances transcriptional activity of androgen receptor through hypoxia-inducible factor-1α in a low androgen environment.
Mitani T, Yamaji R, Higashimura Y, Harada N, Nakano Y, and Inui H.
[J. Steroid Biochem. Mol. Biol., 123, 58-64, 2011]

3. Inhibitory mechanisms of the transcriptional activity of androgen receptor by resveratrol: Implication of DNA binding and acetylation of the receptor.
Harada N, Atarashi K, Murata Y, Yamaji R, Nakano Y, and Inui H.
[J. Steroid Biochem. Mol. Biol., 123, 65-70, 2011]

4. Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells.
Higashimura Y, Nakajima Y, Yamaji R, Harada N, Shibasaki F, Nakano Y, and Inui H.
[Arch. Biochem. Biophys., 509, 1-8, 2011]

5. Kelch-like 20 up-regulates the expression of hypoxia-inducible factor-2α through hypoxia- and von Hippel-Lindau tumor suppressor protein-independent regulatory mechanisms.
Higashimura Y, Terai T, Yamaji R, Mitani T, Ogawa M, Harada N, Inui H, and Nakano Y.
[Biochem. Biophys. Res. Commun., 413, 201-205, 2011]

6. Suppression of inducible nitric oxide synthase expression and amelioration of lipopolysaccharide-induced liver injury by polyphenolic compounds in Eucalyptus globulus leaf extract.
Sugimoto K, Sakamoto S, Nakagawa K, Hayashi S, Harada N, Yamaji R, Nakano Y, and Inui H.
[Food Chem., 125, 442-446, 2011]

7. (-)-Epigallocatechin-3-gallate suppresses growth of AZ521 human gastric cancer cells by targeting the DEAD box RNA helicase p68.
Tanaka T, Ishii T, Mizuno D, Mori T, Yamaji R, Nakamura Y, Kumazawa S, Nakayama T, and Akagawa M.
[Free Radic. Biol. Med., 50, 1324-1335, 2011]

8. Purification, characterization and gene cloning of two forms of a thermostable endo-xylanase from Streptomyces sp. SWU10.
Deesukon W, Nishimura Y, Harada N, Sakamoto T, and Sukhumsirichart W.
[Process Biochem., 46, 2255-2262, 2011]

 

2010
1. Involvement of three glutamine tracts in human androgen receptor transactivation.
Harada N, Mitani T, Higashimura Y, Yamaji R, Okamoto K, Nakano Y, and Inui H.
[J. Steroid Biochem. Mol. Biol., 118, 77-84, 2010]

2. Construction of a dominant negative form of human hypoxia-inducible factor-2α.
Higashimura Y, Yamaji R, Harada N, Nakao M, Nakano Y, and Inui H.
[Biosci. Biotech. Biochem., 74, 2100-2102, 2010]

3. A yeast bioassay for androgenic and anti-androgenic compounds based on the NH2– and COOH-terminal interaction of androgen receptor.
Ogawa M, Yamaji R, Mitani T, Murata Y, Nakao M, Harada N, Nakano Y, and Inui H.
[Biosci. Biotechnol. Biochem., 74, 1965-1968, 2010]

4. Eucalyptus leaf extract suppresses the postprandial elevation of portal, cardiac and peripheral fructose concentrations after sucrose ingestion in rats.
Sugimoto K, Hosotani T, Kawasaki T, Nakagawa K, Hayashi S, Nakano Y, Inui H, and Yamanouchi T.
[J. Clin. Biochem. Nutr., 46, 205-211, 2010]

5. Digestion and absorption of siraitia grosvenori triterpenoids in the rat.
Murata Y, Ogawa T, Suzuki YA, Yoshikawa S, Inui H, Sugiura M, and Nakano Y.
[Biosci. Biotechnol. Biochem., 74, 673-676, 2010]

6. Methyladeninylcobamide functions as the cofactor of methionine synthase in a Cyanobacterium, Spirulina platensis NIES-39.
Tanioka Y, Miyamoto E, Yabuta Y, Ohnishi K, Fujita T, Yamaji R, Misono H, Shigeoka S, Nakano Y, Inui H, and Watanabe F.
[FEBS Lett., 584, 3223-3226, 2010]

7. Sensitive and convenient yeast reporter assay for high-throughput analysis by using a secretory luciferase from Cypridina noctiluca.
Tochigi Y, Sato N, Sahara T, Wu C, Saito S, Irie T. Fujibuchi W, Goda T, Yamaji R, Ogawa M, Ohmiya Y, and Ohgiya S.
[Anal. Chem., 82, 5768-5776, 2010]

 

2009
1. Cobalamin deficiency results in an abnormal increase in L-methylmalonyl-CoA mutase expression in rat liver and COS-7 cells.
Nakao M, Hironaka S, Harada N, Adachi T, Bito T, Yabuta Y, Watanabe F, Miura T, Yamaji R, Inui H, and Nakano Y.
[Brit. J. Nutr., 101, 484-490, 2009]

2. Inhibitive effects of alkyl gallates on hyaluronidase and collagenase.
Barla F, Higashijima H, Funai S, Sugimoto K, Harada N, Yamaji R, Fujita T, Nakano Y, and Inui H.
[Biosci. Biotechnol. Biochem., 73, 2335-2337, 2009]

3. Occurrence of pseudovitamin B12 and its possible function as the cofactor of cobalamin-dependent methionine synthase in a cyanobacterium Synechocystis sp. PCC6803.
Tanioka Y, Yabuta Y, Yamaji R, Shigeoka S, Nakano Y, Watanabe F, and Inui H.
[J. Nutr. Sci. Vitaminol., 55, 518-521, 2009]

4. Rats fed fructose-enriched diets have characteristics of nonalcoholic hepatic steatosis.
Kawasaki T, Igarashi K, Koeda T, Sugimoto K, Nakagawa K, Hayashi S, Yamaji R, Inui H, Fukusato T, and Yamanouchi T.
[J. Nutr., 139, 2067-2071, 2009]

5. Hydrolyzable tannins as antioxidants in the leaf extract of Eucalyptus globulus possessing tyrosinase and hyaluronidase inhibitory activities.
Sugimoto K, Nakagawa K, Hayashi S, Amakura Y, Yoshimura M, Yoshida T, Yamaji R, Nakano Y, and Inui H.
[Food Sci. Technol. Res., 15, 331-336, 2009]

 

2008
1. RanBP10 acts as a novel coactivator for the androgen receptor.
Harada N, Yokoyama T, Yamaji R, Nakano Y, and Inui H.
[Biochem. Biophys. Res. Commun., 368, 121-125, 2008]

2. ARA24/Ran enhances the androgen-dependent NH2– and COOH-terminal interaction of the androgen receptor.
Harada N, Ohmori Y, Yamaji R, Higashimura Y, Okamoto K, Isohashi F, Nakano Y, and Inui H.
[Biochem. Biophys. Res. Commun., 373, 373-377, 2008]

3. Vitamin B12 deficiency results in abnormal regulation of serine dehydratase and tyrosine aminotransferase activities correlatad with impairment of the adenylyl cyclase system in rat liver.
Ebara S, Nakao M, Tomoda M, Yamaji R, Watanabe F, Inui H, and Nakano Y.
[Brit. J. Nutr., 99, 503-510, 2008]

4. Analysis of vitamin B12 in food by silica gel 60 TLC and bioautography with vitamin B12-dependent Escherichia coli 215.
Tanioka Y, Yabuta Y, Miyamoto E, Inui H, and Watanabe F.
[J. Liq. Chromatogr. Relat. Technol., 31, 1977-1985, 2008]

5. Covalent modification of proteins by green tea polyphenol (-)-epigallocatechin-3-gallate through autoxidation.
Ishii T, Mori T, Tanaka T, Mizuno D, Yamaji R, Kumazuwa S, Nakayama T, and Akagawa M.
[Free Radic. Biol. Med., 45, 1384-1394, 2008]

 

2007
1. Glyceraldehyde-3-phosphate dehydrogenase enhances transcriptional activity of androgen receptor in prostate cancer cells.
Harada N, Yasunaga R, Higashimura Y, Yamaji R, Fujimoto K, Moss J, Inui H, and Nakano Y.
[J. Biol. Chem., 282, 22651-22661, 2007]

2. Resveratol down-regulates the androgen receptor at the post-translational level in prostate cancer cells.
Harada N, Murata Y, Yamaji R, Miura T, Inui H, and Nakano Y.
[J. Nutr. Sci. Vitaminol., 53, 556-560, 2007]

3. Antidiabetic effect of long-term supplementation with Siratia grosvenorion the spontaneously diabetic Goto-Kakizaki rat.
Suzuki YA, Tomoda M, Murata Y, Inui H, Sugiura M, and Nakano Y.
[Brit. J. Nutr., 97, 770-775, 2007]

 

2006
1. Abnormal increase in the expression level of proliferation cell nuclear antigen (PCNA) in the liver and hepatic injury in rats with dietary cobalamin deficiency.
Nakao M. Kono N. Adachi S. Ebara S. Adachi T. Miura. T. Yamaji R. Inui H, and Nakano Y.
[J. Nutr. Sci. Vitaminol., 52, 168-173, 2006]

2. Purification and characterization of a corrinoid-compound in an edible cyanobacterium Aphanizomenon flos-aquae as a nutritional supplementary food.
Miyamoto E, Tanioka Y, Nakao M, Barla F, Inui H, Fujita T, Watanabe F, and Nakano Y.
[J. Agric. Food Chem., 54, 9604-9607, 2006]

3. Recent advances in molecular pharmacology of the histamine systems: organic cation transporters as a histamine transporter and histamine metabolism.
Ogasawara M, Yamauchi K, Satoh YI, Yamaji R, Inui K, Jonker JW, Schinkel AH, and Maeyama K.
[J. Pharmacol. Sci., 101, 24-30, 2006]

4. Separation and properties of two novel NADP+-dependent alcohol dehydrogenases from Euglena gracilis Z.
Munir I, Swati ZA, Rashid MH, Yamaji R, Inui H, and Nakano Y.
[Pak. J. Biol. Sci., 6, 2743-2747, 2006]

5. Subcellular localization of glyoxylate cycle key enzymes involved in oxalate biosynthesis of wood-destroying basidiomycete Fomitopsis palustris grown on glucose.
Sakai S, Nishide T, Munir E, Baba K, Inui H, Nakano Y, Hattori T, and Shimada M.
[Microbiology, 152, 1857-1866, 2006]

6. Sweetness characteristics of the triterpene glycosides in Siraitia grosvenori.
Murata Y, Yoshikawa S., Suzuki YA, Sugiura M, Inui H, and Nakano Y.
[Nippon Shokuhin Kagaku Kogaku Kaishi, 53, 527-533, 2006]

 

2005
1. Glyceraldehyde-3-phosphate dehydrogenase in the extracellular space inhibits cell spreading.
Yamaji R, Chatani E, Harada N, Sugimoto K, Inui H, and Nakano Y.
[Biochim. Biophys. Acta, 1726, 261-271, 2005]

2. Eucalyptus leaf extract inhibits intestinal fructose absorption, and suppresses adiposity due to dietary sucrose in rats.
Sugimoto K, Suzuki J, Nakagawa K, Hayashi S, Enomoto T, Fujita T, Yamaji R, Inui H, and Nakano Y.
[Brit. J. Nutr., 93, 957-963, 2005]

3. Triterpene glycosides of Siraitia grosvenori inhibit rat intestinal maltase and suppress the rise in blood glucose level after a single oral administration of maltose in rats.
Suzuki YA, Murata Y, Inui H, Sugiura M, and Nakano Y.
[J. Agric. Food Chem., 53, 2941-2946, 2005]

4. Molecular characterization of a bifunctional glyoxylate cycle enzyme, malate synthase/isocitrate lyase, in Euglena gracilis.
Nakazawa M, Minami T, Teramura K, Kumamoto S, Hanato S, Takenaka S, Ueda M, Inui H, Nakano Y, and Miyatake K.
[Comp. Biochem. Physiol. B, 141, 445-452, 2005]

 

2004
1. Hypoxic up-regulation of triosephosphate isomerase expression in mouse brain capillary endothelial cells.
Yamaji R, Fujita K, Nakanishi I, Nagao K, Naito M, Tsuruo T, Inui H, and Nakano Y.
[Arch. Biochem. Biophys., 432, 332-342, 2004]

2. Characterization of corrinoid compounds from a Japanese black tea (Batabata-cha) fermented by bacteria.
Kittaka-Katsura H, Ebara S, Watanabe F, and Nakano Y.
[J. Agric. Food Chem., 52, 909-911, 2004]

3. Purification and characterization of methylmalonyl-CoA mutase from a photosynthetic coccolithophorid alga, Pleurochrysis carterae.
Miyamoto E, Watanabe F, Yamaguchi Y, Takenaka H, and Nakano Y.
[Comp. Biochem. Physiol. B, 138, 163-167, 2004]

4. Effect of carotenoids and ascorbic acid of Japanese persimmons on cellular lipid peroxidation in HepG2 cells.
Hosotani K, Kawahata A, Koyama K, Murakami C, Yoshida H, Yamaji R, Inui H, and Nakano Y.
[Biofactors, 21, 241-245, 2004]

5. Induction and functional analysis of two reduced nicotinamide adenine dinucleotide phosphate-dependent glutathione peroxidase-like proteins in Synechocystis PCC 6803 during the progression of oxidative stress.
Gaber A, Yoshimura K, Tamoi M, Takeda T, Nakano Y, and Shigeoka S.
[Plant Physiol., 136, 2855-2861, 2004]

6. Enzymatic high digestion of soybean milk residue (okara).
Kasai N, Murata A, Inui H, Sakamoto T, and Kahn RI.
[J. Agric. Food Chem., 52, 5709-5716, 2004]

 

2003
1. Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+/Ca2+ exchanger.
Yamaji R, Fujita K, Takahashi S, Yoneda H, Nagao K, Masuda W, Naito M, Tsuruo T, Miyatake K, Inui H, and Nakano Y.
[Biochim. Biophys. Acta, 1593, 269-276, 2003]

2. Hypoxia-induced megaloblastosis in vitamin B12-deficient rats.
Ebara S, Adachi S, Takenaka S, Enomoto T, Watanabe F, Yamaji R, Inui H, and Nakano Y.
[Brit. J. Nutr., 89, 441-444, 2003]

3. Nitric oxide synthase induction, cGMP elevation, and biopterin synthesis in vascular smooth muscle cells stimulated with interleukin-1β in hypoxia.
Nagao K, Takanaka S, Yamaji R, Inui H, and Nakano Y.
[J. Biochem., 133, 501-505, 2003]

4. Purification and characterization of homodimeric methylmalonyl-CoA mutase from Sinorhizobium meliloti.
Miyamoto E, Watanabe F, Charles TC, Yamaji R, Inui H, and Nakano Y.
[Arch. Microbiol., 180, 151-154, 2003]

5. Presence of glyoxylate cycle enzymes in the mitochondria of Euglena gracilis.
Ono K, Kondo M, Osafune T, Miyatake K, Inui H, Kitaoka S, Nishimura M, and Nakano Y.
[J. Eukaryot. Microbiol., 50, 92-96, 2003]

6. Translational regulation of histamine N-methyltransferase.
Ogasawara M, Yamauchi K, Yamaji R, and Maeyama, K.
[J. Pharmacol. Sci., 91, 109P Suppl. 1]

7. Effect of UV screens and preservatives on vitellogenin and choriogenin production in male medaka (Oryzias latipes).
Inui M, Adachi T, Takenaka S, Inui H, Nakazawa M, Ueda M, Watanabe H, Mori C, Iguchi T, and Miyatake K.
[Toxicology, 194, 43-50, 2003]

 

2002
1. Purification and characterization of a corrinoid compound from chlorella tablets as an algal health food.
Kittaka-Katsura H, Fujita T, Watanabe F, and Nakano Y.
[J. Agric. Food Chem., 50, 4994-4997, 2002]

2. Uptake and physiological function of vitamin B12 in a photosynthetic unicellular coccolithophorid alga, Pleurochrysis carterae.
Miyamoto Y, Watanabe F, Takenaka H, and Nakano Y.
[Biosci. Biotech. Biochem., 66, 195-198, 2002]

3. Occurrence of a novel NADP+-linked alcohol dehydrogenase in Euglena gracilis.
Iqbal M, Nakazawa M, Harano K, Yamaji R, Inui H, Miyatake K, and Nakano Y.
[Comp. Biochem. Physiol., B132, 535-540, 2002]

4. Purification and characterization of Methylmalonyl-CoA mutase from a methanol-utilizing bacterium, Methylobacterium extorquens NR.
Miyamoto E, Watanabe F, Yamaji R, Inui H, Sato K, and Nakano Y.
[J. Nutr. Sci. Vitaminol., 48, 242-246, 2002]

5. Effects of epigallocatechin 3-O-gallate on cellular antioxidative system in HepG2 cells.
Murakami C, Hirakawa Y, Inui H, Nakano Y, and Yoshida H.
[J. Nutr. Sci. Vitaminol., 48, 89-94, 2002]

6. Effect of tea catechins on cellular lipid peroxidation and cytotoxicity in HepG2 cells.
Murakami C, Hirakawa Y, Inui H, Nakano Y, and Yoshida H.
[Biosci. Biotechnol. Biochem., 66, 1559-1562, 2002]

 

2001
1. Inflammatory responses to lipopolysaccharide are suppressed in 40% energy-restricted mice.
Matsuzaki J, Kuwamura M, Yamaji R, Inui H, and Nakano Y.
[J. Nutr., 131, 2139-2144, 2001]

2. Cobalamin deficiency results in severe metabolic disorder of serine and threonine in rats.
Ebara S, Toyoshima T, Matsumura T, Adachi S, Takenaka S, Yamaji R, Watanabe F, Miyatake K, Inui H, and Nakano Y.
[Biochim. Biophys. Acta, 1568, 111-117, 2001]

3. Characterization of a Vitamin B12 Compound from Unicellular Coccolithophorid Alga (Pleurochrysis carterae).
Miyamoto E, Watanabe F, Ebara S, Takenaka S, Takenaka H, Yamaguchi Y, Tanaka N, Inui H, and Nakano Y.
[J. Agric. Food Chem., 49, 3486-3489, 2001]

4. Inactive corrinoid-compound significantly decreases in spirulina platensis grown in a cobalt-deficient medium.
Watanabe F, Miyamoto E, and Nakano Y.
[J. Agric. Food Chem., 49, 5685-5688, 2001]

5. Feeding dried purple laver (nori) to vitamin B12-deficient rats significantly improves vitamin B12 status.
Takenaka S, Sugiyama S, Ebara S, Miyamoto E, Abe K, Tamura Y, Watanabe F, Tsuyama S, and Nakano Y.
[Brit. J. Nutr., 85, 699-703, 2001]

6. Characterization of a vitamin B12 compounds from edible shellfish, clam, oyster, and mussel.
Watanabe F, Katsura H, Takenaka S, Enomoto T, Miyamoto E, Nakatsuka T, and Nakano Y.
[Int. J. Food Sci. Nutr., 52, 263-268, 2001]

7. Improvement of the flavor of canned satsuma mandarin with the essence.
Takahashi H, Sumitani H, Inada Y, Mori D, and Nakano Y.
[Appl. Biol. Sci., 7, 49-56, 2001]

8. Characterization of monoclonal antibodies against ascorbate peroxidase isoenzymes: purification and epitope-mapping using immunoaffinity column chromatography.
Yoshimura K, Ishikawa T, Wada K, Takeda T, Kamata Y, Tada T, Nishimura K, Nakano Y, and Shigeoka S.
[Biochim. Biophys. Acta, 1526, 168-174, 2001]

9. NADPH-dependent glutathione peroxidase-like proteins (Gpx-1, Gpx-2) reduce unsaturated fatty acid hydroperoxides in Synechocystis PCC 6803.
Gaber A, Tamoi M, Takeda T, Nakano Y, and Shigeoka S.
[FEBS Lett., 499, 32-36, 2001]

10. Expression of a gene encoding chitinase (pCA8ORF) from Aeromonas sp. No. 10S-24 in Escherichia coli enzyme characterization.
Sutrisno A, Ueda M, Inui H, Kawaguchi T, Nakano Y, Arai M, and Miyatake K.
[J. Biosci. Bioeng., 91, 599-602, 2001]

11. Effect of barley on gastric juice secretion in rats with water immersion induced stress ulcer.
Yoshizawa M, Nakano Y, and Nakamura H.
[J. Assoc. Dietary Fiber Res., 5, 21-27, 2001]

 

2000
1. Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex.
Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, and Vaughan M.
[Proc. Natl. Acad. Sci. USA, 97, 2567-2572, 2000]

2. Implanted tumor growth is suppressed and survival is prolonged in sixty percent of food-restricted mice.
Matsuzaki J, Yamaji R, Kiyomiya K, Kurebe M, Inui H, and Nakano Y.
[J. Nutr., 130, 111-115, 2000]

3. Increases in gastric histidine decarboxylase activity and plasma gastrin level in streptozotocin- induced type 1 diabetic rats.
Inui H, Yasuno R, Takenoshita M, Ohnishi Y, Sakamoto M, Matsuzaki J, Yamaji R, Miyatake K, Yamatodani A, and Nakano Y.
[J. Nutr. Sci. Vitaminol., 46, 144-148, 2000]

4. Characterization of a vitamin B12 compound in the edible purple laver, Porphyra yezoensis.
Watanabe F, Takenaka S, Katsura H, Miyamoto E, Abe K, Tamura Y, Nakatsuka T, and Nakano Y.
[Biosci. Biotech. Biochem., 64, 2712-2715, 2000]

5. The improvement of the flavor of canned satsuma mandarin.
Takahashi H, Sumitani H, Inada Y, Mori D, and Nakano Y.
[Appl. Biol. Sci., 6, 67-73, 2000]

6. Effect of light-induced riboflavin degradation on the loss of cobalamin in milk.
Watanabe F, Katsura H, Abe K, and Nakano Y.
[J. Home Econ. Jpn., 51, 231-234, 2000]

7. The origin of pyruvate:NADP+ oxidoreductase in mitochondria of Euglena gracilis.
Nakazawa M, Inui H, Yamaji R, Yamamoto T, Takenaka S, Ueda M, Nakano Y, and Miyatake K.
[FEBS Lett., 479, 155-157, 2000]

 

1999
1. Disordered expression of the sucrase-isomaltase complex in the small intestine in Otsuka Long-Evans Tokushima fatty rats, a model of non-insulin-dependent diabetes mellitus with insulin resistance.
Adachi T, Takenoshita M, Katsura H, Yasuda K, Tsuda K, Seino Y, Enomoto T, Yamaji R, Miyatake K, Inui H, and Nakano Y.
[Biochim. Biophys. Acta, 1426, 126-132, 1999]

2. Purification and characterization of ADP-ribosyl cyclase from Euglena gracilis.
Masuda W, Takenaka S, Tsuyama S, Inui H, Miyatake K, and Nakano Y.
[J. Biochem., 125, 449-453, 1999]

3. Dried green and purple lavers (Nori) contain substantial amounts of biologically active vitamin B12 but less of dietary iodine relative to other edible seaweeds.
Watanabe F, Takenaka S, Katsura H, Mazumder ZH, Abe K, Tamura Y, and Nakano Y.
[J. Agric. Food Chem., 47, 2341-2343, 1999]

4. Pseudovitamin B12 is the predominant cobamide of an algal health food, spirulina tablets.
Watanabe F, Katsura H, Takenaka S, Fujita T, Abe K, Tamura T, Nakatsuka T, and Nakano Y.
[J. Agric. Food Chem., 47, 4736-4741, 1999]

 

1998
1. Suppressive effect of insulin on the synthesis of sucrase-isomaltase complex in small intestinal epithelial cells, and abnormal increase in the complex under diabetic conditions.
Takenoshita M, Yamaji R, Inui H, Miyatake K, and Nakano Y.
[Biochem. J., 329, 597-600, 1998]

2. The intron 5-inserted form of rat erythropoietin receptor is expressed as a membrane-bound form.
Yamaji R, Murakami C, Takenoshita M, Tsuyama S, Inui H, Miyatake K, and Nakano Y.
[Biochim. Biophys. Acta, 1403, 169-178, 1998]

3. Effect of microwave heating on the loss of vitamin B12 in foods.
Watanabe F, Abe K, Fujita T, Goto M, Hiemoti M, and Nakano Y.
[J. Agric. Food Chem., 46, 206-210, 1998]

4. Comparison of microbiological assay and a fully automated chemiluminescent system for the determination of vitamin B12 in food.
Watanabe F, Takenaka S, Abe K, Tamura Y, and Nakano Y.
[J. Agric. Food Chem., 46, 1433-1436, 1998]

5. Biological Activity of Hydroxo-vitamin B12 Degradation Product Formed during Microwave Heating.
Watanabe F, Abe K, Katsura H, Takenaka S, Mazumder ZH, Yamaji R, Ebara S, Fujita T, Tanimori S, Kirihata M, and Nakano Y.
[J. Agric. Food Chem., 46, 5177-5180, 1998]

3. α2-Adrenoceptor-mediated antisecretory effect of hypoxia in conscious rats.
Yamaji R, Ohnishi Y, Sakamoto M, Takenoshita M, Ohta M, Tsuyama S, Watanabe F, Inui H, Miyatake K, and Nakano Y.
[Biosci. Biotech. Biochem., 62, 546-549, 1998]

4. Low Sucrase Activity in the Small Intestine of a Senescence-accelerated Strain of Mouse, SAMP1.
Takenoshita M, Yabune M, Katsura H, Yamaji R, Inui H, Miyatake K, and Nakano Y.
[Biosci. Biotech. Biochem., 62, 965-969, 1998]

5. Suppression by water extracts of sophora plants of sucrose-induced hyperglycemia in rats and inhibition of intestinal disaccharidases in vitro.
Shi H, Huang Q, Yamaji R, Inui H, Fujita T, Miyatake K, Nakano Y, Tada T, and Nishimura K.
[Biosci. Biotech. Biochem., 62, 1225-1227, 1998]

6. Occurrence of vitamin B12 coenzymes in an halotolerant green alga, Dunaliella tertiolecta.
Watanabe F, Abe K, Katsura H, Takenaka S, Mazumder ZH, Tamura Y, and Nakano Y.
[Appl. Biol. Sci., 4, 17-26, 1998]

7. Propionic Acid Metabolism in Euglena gracilis Z I. Effect of Ammonium Ion.
Mazumder, ZH, Inui H, Ueda M, Miyatake K, Haranou K, and Nakano Y.
[Appl. Biol. Sci., 4, 37-46, 1998]

8. Inhibition of Aldose Reductases by α-and β-Glucosides from A Perilla and Possible Implications for Recognition ofα-and β-Glucoside Configuration.
Fujita T, Ohira K, Takenoshita M, Nakatsuka T, Yamaji R, Ueda M, Miyatake K, Nakayama M, and Nakano Y.
[Appl. Biol. Sci., 4, 123-134, 1998]

9. Effects of CO2 and O2 concentrations and light intensity on growth of microalgae (Euglena gracilis) in CELSS.
Kitaya Y, Kibe S, Oguchi M, Tanaka H, Miyatake K, and Nakano Y.
[Life Support Biosph. Sci., 5, 243-247, 1998]

 

1997
1. Oscillation of ADP-ribosyl cyclase activity during the cell cycle and function of cyclic ADP-ribose in a unicellular organism, Euglena gracilis.
Masuda W, Takenaka S, Inageda K, Nishina H, Takahashi K, Katada T, Tsuyama S, Inui H, Miyatake K, and Nakano Y.
[FEBS Lett., 405, 104-106, 1997]

2. Method for quantitation of total vitamin B12 in foods using a highly fluorescent vitamin B12 derivative.
Watanabe F, Abe K, Takenaka S, Fujita T, and Nakano Y.
[J. Agric. Food Chem., 45, 4661-4663, 1997]

3. Inositol 1,4,5-trisphosphate and dyclic ADP-ribose mobilize Ca2+ in a protist, Euglena gracilis.
Masuda W, Takenaka S, Tsuyama S, Tokunaga M, Yamaji R, Inui H, Miyatake K, and Nakano Y.
[Comp. Biochem. Physiol., 118C, 279-283, 1997]

4. Accumulation of trehalose as a compatible solute under osmotic stress in Euglena gracilis Z.
Takenaka S, Kondo T, Nazeri S, Tamura Y, Tokunaga M, Tsuyama S, Miyatake K, and Nakano Y.
[J. Euk. Microbiol., 44, 609-613, 1997]

5. Effect of carnosine and anserine on the destruction of vitamin B12 with vitamin C in the presence of copper.
Takenaka S, Sugiyama S, Watanabe F, Abe K, Tamura Y, and Nakano Y.
[Biosci. Biotech. Biochem., 61, 2137-2139, 1997]

6. Occurrence of Cobalamin Coenzymes in the Photosynthetic Green Alga.
Watanabe F, Abe K, Takenaka S, Tamura Y, Maruyama I, and Nakano Y.
[Biosci. Biotech. Biochem., 61, 896-897, 1997]

7. Salt-torerant Mechanism of a Protozoan, Eugelana gracilis Z.
Nakano Y, Miyatake K, Watanabe F, and Takenaka, S.
[Salt Sci. Res. Foundation Ann. Res. Rep., 367-376, 1997]

8. Growth of Euglena, a photosynthetic alga, by light emitting diodes.
Aiga I, Kiyota M, Matsumoto T, Yamaji R, Nakano Y, Miyatake K, Takenaka S, Masuda W, Jinda T, Horaguchi K, Wasa K, and Kondo J.
[CELSS J., 9, 7-12, 1997]

 

1996
1. Brain capillary endothelial cells express two forms of erythropoietinreceptor mRNA.
Yamaji R, Okada T, Naito M, Tsuruo T, Miyatake K, and Nakano Y.
[Eur. J. Biochem., 239, 494-500, 1996]

2. Hypoxia inhibits gastric emptying and gastric acid secretion in conscious rats.
Yamaji R, Sakamoto M, Miyatake K, Nakano Y.
[J. Nutr., 126, 673-680, 1996]

3. Mitochondrial NADH-linked aquacobalamin reductase activity is low in human skin fibroblasts with defects in synthesis of cobalamin coenzymes.
Watanabe F, Saido H, Yamaji R, Miyatake K, Isegawa Y, Ito A, Yubisui T, Rosenblatt DS, and Nakano Y.
[J. Nutr., 126, 2947-2951, 1996]

4. Effect of cobalamin deficiency on the biosynthesis of phosphatidylcholine in Euglena gracilis.
Inui H, Ohya O, Isegawa Y, Kitaoka S, Miyatake K, and Nakano Y.
[J. Euk. Microbiol., 43, 177-180, 1996]

5. Accumulation of methylmalonic acid caused by vitamin B12-deficiency disrupts normal cellular metabolism in rat liver.
Toyoshima S, Watanabe F, Saido H, Pezacka E, Jakobsen D, Miyatake K, and Nakano Y.
[Brit. J. Nutr., 75, 929-938, 1996]

6. Purification and characterization of arginine: mono-ADP-ribosylhydrolase from Euglena gracilis Z.
Takenaka S, Masuda W, Tsuyama S, Tamura Y, Miyatake K, and Nakano Y.
[J. Biochem., 120, 792-796, 1996]

7. Adenosylcobalamin-dependent methylmalonyl-CoA mutase isozymes in the phtosynthetic protozoon Euglena gracilis Z.
Watanabe F, Abe K, Tamura Y, and Nakano Y.
[Microbiology, 142, 2631-2634, 1996]

8. Characterization of niacin of skipjack tuna muscle and change of the niacin content during storage.
Watanabe F, Goto M, Abe K, Nakano Y.
[J. Jpn. Soc. Cold Preserva. Food, 22, 165-168, 1996]

9. Glutathione peroxidase activity during storage of fish muscle.
Watanabe F, Goto M, Abe K, and Nakano Y.
[J. Food Sci., 61, 734-735, 1996]

10. Euglena gracilis fermentative wax ester production.
Abe K, Watanabe F, Masuda W, Inui H, Miyatake K, and Nakano Y.
[Appl. Biol. Sci., 2, 33-40, 1996]

11. Different location in dark-adapted leaves of phaseolus vulgaris of ribulose-1,5-bisphosphatecarboxylase/oxygenase and2-carboxyarabinitol 1-phosphste.
Anwaruzzaman, Nakano Y, and Yokota A.
[FEBS Lett., 388, 223-227, 1996]

12. Purification and Characterization of Serine Hydroxymethyltransferase from Mitochondria of Euglena gracilis Z.
Sakamoto M, Masuda T, Yanagimoto Y, Nakano Y, Kitaoka S, and Tanigawa Y.
[Biosci. Biotech. Biochem., 60, 1941-1944, 1996]

13. Growth of photosynthetic algae Euglena in high CO2 conditions and its photosynthetic characteristics.
Nakano Y, Miyatake K, Okuno H, Hamazaki K, Takenaka S, Honami N, Kiyota M, Aiga I, and Kondo J.
[Acta Hort.,440, 49-54, 1996]

14. K project: production of food by biological fixation of CO2.
Kondo J, Aiga I, Nakano Y, and Miyatake K.
[Acta Hort., 440, 645-650, 1996]